CASE REPORT  
Niger J Paed 2014; 41 (3): 239 –243  
Amuabunos AE  
Eregie CO  
Omoigberale AI  
Effiong V  
Conjoined twins in Edo state of  
Nigeria; a report of the first  
surviving set  
DOI:http://dx.doi.org/10.4314/njp.v41i3,17  
Accepted: 8th March 2014  
Abstract:  
The term conjoined  
delivered in 2009 and survived a  
separation surgery. A third set of  
female thoracoomphalopagus was  
delivered in another institution  
same year and referred to our unit  
but they only survived for 48  
hours.  
The first surviving twins were om-  
phalopagus, sharing a single liver,  
and common bile duct emptying  
into a common duodenum. The  
stomach, as well as the jejunum  
was normal and unshared. Surgical  
separation of the liver was done  
and biliary reconstruction proce-  
dure performed for twin II. A three  
-year follow up showed good out-  
come.  
twins refers to babies who are  
physically joined at some point. It  
is a rare condition with an esti-  
mated incidence of 1 per 200,000  
live births. We report our experi-  
ence with conjoined twins over a  
twelve year period in tertiary hos-  
pital in Nigeria and a case of the  
first set of conjoined twin survivors  
in Benin City, Nigeria. Over the  
last twelve years (1999-2011),  
three cases of conjoined twin have  
been recorded in our teaching hos-  
pital. A set of thoracoomphalo-  
pagus twins (females) were deliv-  
ered in 1999 and they survived for  
only 36hrs. Another set of female  
omphalopagus twins were  
Amuabunos AE  
Eregie CO  
(
)
Omoigberale AI  
Department of Child Health,  
Effiong V  
Neonatal Unit  
University of Benin Teaching hospital,  
Ugbowo, Benin City,  
PMB 1111, Edo State, Nigeria.  
Email: amua4@yahoo.com  
Introduction  
nancy. Overall the condition is rare with an estimated  
incidence of 1 per 200,000 live births . Though there are  
4
The care of conjoined twins continues to pose a daunt-  
ing medical challenge that includes adequate care of  
pregnancy, well planned delivery, critical care in early  
neonatal life, advance surgical intervention and last but  
more live born females conjoined twin with a female to  
male ration of 3:1, however this condition occur more in  
male foetuses as evidenced by its higher rates in male  
stillborn. Male conjoined twins are also more likely to  
die shortly after birth, implying that female conjoined  
foetuses have better chance at survival than their male  
counterparts.  
The site of union forms the basis of the terms used for  
classifying conjoined twins: Thoracoomphalopagus  
(joined at the chest, abdomen or both) – 74%  
1
,2  
not the least is the ethical issues . We report our experi-  
ence with conjoined twins over a twelve year period in a  
tertiary hospital in Nigeria and a case of the first set of  
conjoined twin survivors in Benin City, Nigeria. The  
incidence of conjoined twins in Nigeria is unknown;  
however an article published in 2001 suggests that over  
the preceding 60 years there were 12 published cases  
Thoracopagus or xiphopagus ( joined at the chest) - 40%  
Omphalopagus (joined at the abdomen) - 34%  
3
nationwide, excluding our own cases. The cases seen in  
our center have so far not been reported perhaps because  
this center had not recorded any survival of conjoined  
twins since its existence three and half decades ago.  
Therefore under reporting may be due to the poor prog-  
nosis and stigmatization associated with this condition.  
Pygopagus (joined at the buttocks) – 18%  
Ischiopagus (joined at the ischium) – 6%  
Craniopagus (joined at the head) – 2%  
A rare type occurs when one incompletely formed  
(parasitic) twin is dependent on the well-formed one.  
This is known as heteropagus twinning. The term  
“pagus” is a Greek word which means “that which is  
fixed”  
The term Siamese twins comes from Eng and Chang  
Bunker (1811-1874), the famous conjoined twins from  
Thailand (previously known as Siam). They were thora-  
copagus twins and were exhibited in circus shows  
around the world before settling in the United States,  
where they married two sisters and had nearly two dozen  
children. They were successful businessmen and lived  
up to 63 years. There have been several other reports of  
Conjoined twining is one of the most fascinating human  
malformations but it is not exclusive to our specie as it  
has also been reported in other mammals, reptiles, birds  
4
and fishes. The term conjoined twins refers to babies  
who are physically joined at some point. It results from  
incomplete splitting of monozygotic (identical) twins  
after 12 days of embryogenesis. Some authors recently  
had postulated that it actually results from “fusion” of  
4
stem cells of already separated embryo . Conjoined  
twinning occurs sporadically with no risk in future preg-  
2
40  
conjoined twins in different parts of the globe. In Nige-  
ria the earliestth report of conjoined twins were born in  
Sokoto on 20 December 1935 to a 25 year old para 3  
sporadic, howbeit scanty, reports of conjoined twin from  
the country, but a three year survival follow up of the  
survivors is generally scarce. Since the first documenta-  
tion in 1935 till date, 18 cases have so far been reported  
as summarized in table 1. There are, nonetheless, some  
cases of conjoined twins that were found in the Nigerian  
news reports that never made the medical literature,  
Table 2  
5
woman at home. They shared only abdominal wall and  
skin, but no shared internal organs. They were readily  
separated at the General Hospital in Sokoto by a British  
5
missionary doctor. Twenty years later the Kano ompha-  
lopagus twins Tamonotanye and Waiboko, were sepa-  
6
rated in London by Ian Ard. Since then there have been  
Table 1: Summary of conjoined twin reported from Nigeria  
Place of delivery Author(s)  
Type of Conjoin Twins No of pairs Place of surgery  
Outcome  
Twin I Twin II  
Sokoto  
Kano  
Port Harcourt  
McLaren, 1936  
Aird, 1945  
Holgate and  
Omphalopagus  
Omphalopagus  
Omphalopagus  
1
1
1
Sokoto General Hospital  
Hammersmith, UK  
Enugu General Hospital  
S
S
S
S
D
S
Ikpeme, 1956  
Stigglebout, 1958  
Gupta, 1966  
Kaduna  
Ibadan  
Thoracopagus  
Pygopagus  
Thoracopagus  
1
1
1
-
Hammersmith, UK  
UCH, Ibadan  
Still Born  
S
D
Still Born  
D
D
Omokhodion et al,  
2
001  
Warri  
Zaria  
Bankole et al, 1972  
Mabogunje, 1978  
Ischiopagus  
Omphalopagus  
Thoracopagus  
Dicephalus  
1
1
1
1
1
UCH, Ibadan  
ABUTH, Zaria  
D
D
Still Born  
Still Born  
S
D
D
Still Born  
Still Born  
D
1
980  
980  
Sathiakumar et al,  
990  
1
Pygopagus  
1
NDU Sule  
Anambra  
Mabogunje and  
Lawrie, 1978  
Iroku and Anah,  
Heteropagus  
Pygopagus  
1
1
1
S
-
UNTH, Enugu  
D
D
1
990  
Lagos  
Ile-Ife  
*2003  
Adejuyigbe et al,  
005  
Thoraco-abdomino pagus  
Ischiopagus  
John Hopkins, Baltimor  
OAUTHC, Ile-Ife  
S
S
S
S
2
2
Enugu  
Maiduguri  
Ekenze et al, 2009  
Auwal et al, 2011  
Omphalopagus  
Ischiopagus  
1
1
Germany  
UMTH, Maiduguri  
S
S
S
S
*Total  
18  
*Total excluded the conjoined twins seen at the UBTH between 1999 and 2011  
Table 2: News reports of Nigerian conjoined twins  
Gender  
Date  
Birth place  
Extent of joining  
Place of surgery Website  
Chest  
??  
2005  
Owerri  
Abdomen  
www.allafrica.com/stories/200503040379.html  
Pelvic girdle  
Genitalia  
F
F
2013  
2012  
Oturkpo  
Kano  
Abdomen  
Pyopagus  
www.newsinnigeria.org/2013/18  
www.punchng.com  
India  
Heart  
Chest to abdomen  
Upper intestines  
Thoracoomphalopagus  
One heart  
F
M
2013  
2013  
Nasarawa  
Enugu  
www.news2.onlinenigeria.com  
www.nigerianuniversitynews.com/2013/06  
Joined genitals  
F
2011  
Jos  
Parasite twin – no head Ibadan  
Chest down  
www.enownow.com  
3
legs  
One liver  
One intestine  
www.dailytrust.info/index.php/city-news/2010  
-abuja  
M
F
2013  
2004  
Abuja  
www.nigerianmonitor.com  
www.business,highbeam.com/3548/article-IGI  
Abakaliki  
??  
-121544947  
Surgical separation of conjoined twins that results in the  
death of one, or both, of the twins raises complex moral,  
ethical and legal issues. Where organs such as brain or  
heart are shared there is a great risk of one or both twins  
dying if attempt is made at separation. Indeed, any  
shared organ is often not shared equally and the question  
often arises as to who should be left with what. Of par-  
ticular concern is the potential for homicide charges  
against doctors. The parents of the Manchester twins,  
2
Mary and Jodie born in 2000, refused to grant permis-  
sion for surgery, despite the judges’ ruling in favour of  
surgery. A circumstance, where Mary was sacrificed at  
surgery7, was argued by some as “a murder Mary to save  
Jodie”.  
2
41  
Over the last twelve years (1999-2011), three sets of live  
conjoined twins were documented in our teaching hospi-  
tal. The hospital has an average annual delivery rate of  
Twins I and II weighed 4.7kg and 4.8kg respectively  
after surgery. At 2 years postnatal age they weighed 8.5  
and 8.6kg respectively while at 3 years they weighed  
13.4kg and 13.6kg. Their psychomotor development  
was compatible with their age at 18 months using the  
Bailey Developmental Scale. Thorough clinical and  
laboratory re-evaluation at age three, paying particular  
attention to the cardiovascular, digestive and renal sys-  
tems of the twins yielded normal findings.  
1
,600 and serves as a major referral center for a popula-  
tion of approximately six million people. There were  
two thoracoomphalopagus and one omphalopagus twins.  
One set of the thoracoomphalopagus twins was deliv-  
ered elsewhere. Both sets of thoracoomphalopagus twins  
died within 48 hours following birth.  
Case  
Fig 1: The  
conjoined  
twins at two  
weeks of life  
th  
The surviving twins were delivered on the 9 of Sep-  
tember 2009 at 02:48hrs to a young couple at the Uni-  
versity of Benin Teaching Hospital, in Benin City, Edo  
State which is in the South-South part of Nigeria. Their  
mother, a 29 year old lady registhtered this first pregnancy  
at our health facility at the 19 week of gestation. Ob-  
stetric ultrasound scan done at her antenatal booking  
revealed that she had a set of omphalopagus twins. The  
antenatal period remained otherwise unremarkable until  
Fig 2: After surgery  
th  
the 34 week of gestation when she went into spontane-  
ous preterm labour. She was delivered of live female  
omphalopagus twins by an emergency Caesarian Section  
Twin I  
(
Fig 1). The twins were both small-for-dates. They had a  
combined birth weight of 3.4kg but the Apgar Scores  
were good. They were joined at the level of the xiphis-  
ternum to a point just above the umbilicus. There was a  
small exomphalos with separate umbilical cords. They  
both had mild respiratory distress syndrome which  
resolved within 72hrs following delivery. On the third  
day of life they developed jaundice requiring photother-  
apy: the highest bilirubin levels were 13.2 for twin 1 and  
Twin II  
1
3.5mg/dl or twin 2. They were treated for Escherichia  
coli sepsis with ciprofloxacin and gentamycin guided by  
the antibacterial sensitivity. By the third week of life  
they had shown evidence of full recovery and had re-  
gained their combined birth weight. From the fourth  
week they were on full milk feeds and had satisfactory  
growth.  
Thoraco-abdominal CT scan revealed that they both  
shared a single liver and proximal part of the gut. Twin I  
had dextrocardia without any functional abnormality.  
Extensive evaluation of the other systems was normal.  
Discussion  
They remained in our newborn unit, until the age of nine  
months. Their combined weight was 9.8 kg, and a sepa-  
ration surgery was then performed at the Narayana hos-  
pital in Bangalore, India. Findings at surgery included a  
single liver that was “fused” in the midline with separate  
blood supplies. There was a common gallbladder and  
bile duct that emptied into a common duodenum which  
extended up to about 20cm in length. Each twin had her  
own stomach and jejunum. The liver was divided and  
biliary reconstruction procedure done for twin II. The  
duodenum was shared between the two by resection and  
re-anastomosis. The twins required initial thmechanical  
ventilation and were weaned off by the 4 day. Post  
surgery they remained stable and were transferred back  
to the UBTH (fig 2). Physical therapy was instituted to  
enable them “catch-up” with their motor development  
that was hitherto made difficult whilst conjoined.  
This case is a report of the first surviving conjoined  
twins in a decade of conjoined twins history in this cen-  
ter. Overall reporting of conjoined twins is low in the  
country. Review of available literature showed that 18  
cases have been reported across the country in the last  
7
6 years from 1935 to 2012. Five cases, 28%, were re-  
8
ported from a single center in the North, Zaria, 3 while  
9
the other cases were reported from Ibadan, Ife,  
10  
Enugu and few tertiary health centers in other parts of  
the country. The higher report from Zaria may be due to  
the heightened interest of the workers. None so far has  
been reported from Benin and some other tertiary cen-  
ters across the country to enable a more countrywide  
data review. In contrast, 22 cases were reported from a  
single institu1ti1on in Philippines, over a 30 year period  
(
1974-2006). An institution in Sao Paula, Brazil re-  
ported 14 cases over a 25 year period further reflecting  
2
42  
1
2
possible underreporting in Nigeria. It is hoped that this  
report will be an important contribution to the few exist-  
ing publications in the country. Although a small num-  
ber of centers in the country have reported survival of  
conjoined twins, of note is that information on follow up  
morbidity and mortality were generally lacking. Our  
surviving conjoined twins were followed up for catch-up  
growth, psychomotor development, presence of organ  
dysfunction and possible late complications of the sur-  
gery. All these parameters turned out to be normal at the  
age of three years. Due to the complexity of the surgical  
separation, a follow up to evaluate long term survival  
and quality of life is useful reviewing surgical interven-  
tion in the future. In the recent3case of separation of het-  
favourable outcome following surgery. In contrast to  
reports from other parts of the world, the author is un-  
aware of any report of adult conjoined twins in the coun-  
try. This situation may not be surprising as these babies  
might have been deprived of care and left to die largely  
because of stigma, poverty and ignorance. The current  
case required a lot of psycho-social support for the  
young parents who had initially abandoned these babies.  
On the contrary the Biddenden Maids, born in England  
in 1100, were famous and lived for 34 years. The  
Siamese twins were also wealthy and famous in the  
United States. We suggested that providing national  
awareness, special government support and opening  
national conjoined twins’ registry will go a long way in  
improving the outcome of these babies, especially when  
surgery pose a survival risk to one or both twins.  
1
eropagus twins in Maiduguri, the twins had major re-  
constructive surgery, consequently, long term follow up  
of these twins will be complementary to our knowledge.  
All three sets of conjoined twins seen at our center were  
females, which is in keeping with the female preponder-  
ance noted in the literature. Four out of the six babies  
suffered early neonatal deaths while 2 (index twins) sur-  
vived at 3-year follow up. Due to paucity of data it is  
difficult to say, with any degree of accuracy, what the  
still birth rate or neonatal death rate for conjoined twins  
in the country is. Three of the reported 18 pairs where  
still born, all the reported live born had surgery, 11 in  
Nigeria and 4 abroad (Table I). Six out of the eight ba-  
bies (75%) operated abroad survived (one baby was sac-  
rificed to save the other twin). Twelve out of 22 babies  
Conclusion  
There is under reporting of conjoined twins in Nigeria  
compared to other parts of the world. Experience from  
available literature showed that these can be largely pre-  
vented by demystifying the condition, providing more  
awareness and support for the families. These measures  
will go a long way to improving reporting as well as  
enhancing the survival of these babies. Secondly paedia-  
tricians and surgeons in Nigeria might want to review  
their decisions to separate when the risk to one or both  
twins is greater than the risk without the procedure.  
(
54%) operated in Nigeria survived. Success rate was  
fairer with ischio/pygopagus twins (58.3%) and poor  
with thoraco/omphalopagus twins, especially when in-  
ternal organs are shared.  
Authors’ contribution  
Amuabunos AE, Eregie CO, Omoigberale AI  
Effiong V: All managed the patient and reviewed the  
manuscript  
A careful review of the current case with surgeons in our  
institution and consult with other surgeons within and  
outside the country informed the choice of having the  
surgery done abroad to improved the chances of survival  
of both twins considering the shared organs. This re-  
flects the need to build on the already existing capacity  
to handle such cases.  
Conflicts of interest: None  
Funding: None  
While some have questioned the decision to separate  
conjoined twins “when two are born as one”, having the  
Acknowledgement  
2
twins separated may seem justified if it is adjudged that  
one or both twins would die without separation. This is  
the case in some heteropagus twin situations in which  
the parasite twin may die and/or cause the host twin seri-  
ous physiologic embarrassment due to vascular, biliary  
or enteric anastomosis. Even though our omphalopagus  
twins are likely to survive into adulthood, the decision to  
separate was preferential because of the expected  
The authors acknowledge with gratitude the assistance  
of the management of the Narayana Hospital in Banga-  
lore, India and the surgical team especially Professor  
Asley D’Cruz. We also thank the surgical team at the  
university of Benin Teaching Hospital under the leader-  
ship of Professor Evbounwan for their expert and pro-  
fessional contribution to the care of the babies.  
References  
1
.
Davis C. Separating conjoined  
twins: a medical and criminal law  
dilemma. J Law Med. 2010;17  
3. Omokhodion SI, Ladipo JK, Ode-  
4. Spencer R. Conjoined twins: theo-  
retical embryologicbasis. Teratol-  
ogy 1992;45:591–602.  
5. McLaren DW. Separation of con-  
joined twins. Brit Med J 1936;  
ii:971  
bode T O, et al The Ibadan con-  
joined twins: a report of omphalo-  
pagus twins and a review of cases  
reported in Nigeria over 60 years.  
Ann Trop Paediatr. 2001;21  
(3):263  
(4):594-607.  
2
.
Gillett G. When two are born as  
one: the ethics of separating con-  
joined twins. J Law Med. 2009;17  
6. Aird I. The Conjoined Twins of  
Kano. Brit. Med. J 1954 ;1: 831  
(2):184-9.  
2
43  
7
.
Paris JJ, Elias-Jones AC. "Do we  
murder Mary to save Jodie?" An  
ethical analysis of the separation  
of the Manchester conjoined  
10. Ekenze SO, Ibeziako SN, Adimora  
GN, et al. Ruptured omphalocele  
in thoracoomphalopagus conjoined  
twins. Int Surg. 2009;94(3):221-3.  
11. Saguil E, Almonte J, Baltazar W,  
et al Conjoined twins in the Philip-  
pines: experience of a single insti-  
tution. Pediatr Surg Int. 2009 ;25  
(9):775-80  
12. Berezowski AT, Duarte G, Rodri-  
gues R, et al Conjoined twins: an  
experience of a tertiary hospital in  
Southeast Brazil. Rev Bras Ginecol  
Obstet. 2010;32(2):61-5.  
13. Abubakar AM, Ahidjo A, Chinda  
JY, et al The epigastric het-  
eropagus conjoined twins. J Pedi-  
atr Surg. 2011;46(2):417-20  
twins. Postgrad Med J. 2001;77  
(911):593-8.  
8
.
Mabogunje OA, Lawrie JH. Con-  
joined twins in West Africa. Arch  
Dis Child 1980; 55:626–30.  
9
.
Adejuyigbe O, Sowande OA, Ola-  
banji JK, et al. Successful separa-  
tion of two pairs of conjoined  
twins in Ile Ife, Nigeria: case re-  
ports. East Afr Med J. 2005;82  
(1):50-4.